The Quality Target Product Profile (QTPP) serves as a strategic framework for guiding the development of cell therapies, ensuring alignment between clinical goals and regulatory requirements. This recommendation notice highlights the importance of establishing a well-defined QTPP early in the development process to mitigate risks and streamline regulatory approval. It provides practical guidelines for identifying critical quality attributes (CQAs) and offers insights into regulatory expectations specific to cell-based products. By adopting a proactive approach to QTPP, developers can enhance product quality, safety, and efficacy, while optimizing the pathway to market approval.